From San Francisco:

Get on the Bay Bridge, unfortunately, this is really your only choice. When you get back onto "dry land," be sure to be in one of the right-hand lanes.
Take the I-880 S exit towards ALAMEDA/AIRPORT/SAN JOSE. 0.44 miles
Keep RIGHT at the fork in the ramp, exiting at W GRAND AVE/MARITIME AVE EXIT. 0.41 miles
Keep going STRAIGHT, you're on WEST GRAND. a ways miles
Turn LEFT onto BROADWAY
Turn LEFT onto 25TH ST. 0.01 miles
Total Estimated Time:16 minutes (We're pretty sure the Mapquest folks have no concept of Bay Area traffic.)